Publications
Check Ioanna's Google Scholar profile for an up to date list
Book chapters
3. Fusogenic Liposomes to Overcome the Gram-Negative Bacterial Outer Membrane Barrier
Scheeder A. & Mela I.* Advances in Biomembranes and Lipid Self-Assembly, Elsevier, ABL Volume 42: AID 119, in press
2. Targeting bacterial cells with DNA nanostructures,
Scheeder A. & Mela I.*, (2025) DNA Nanotechnology. Methods in Molecular Biology, vol 2901. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4394-5_8
1. Purification of Recombinant ESCRT-III Proteins and Their Use in Atomic Force Microscopy and In Vitro Binding and Phosphorylation Assays.
Capalbo, L., Mela, I., Abad, M.A., Jeyaprakash, A.A., Edwardson, J.M., D’Avino, P.P., Methods Mol Biol, 2019;1998:203-217. doi: 10.1007/978-1-4939-9492-2_15.
Pre-prints
1. Bioelectronic platform enables lectin-based enrichment of columnar cell clusters for Barrett’s oesophagus detection
Pavagada S., Masque-Soler N., Lu Z., Fu Y., Saez J., Ustaoglu A., Bistrovic Popov A., Lizhe Zhuang J., Fruk L., Owens R. M., Fitzgerald R. C. (2025), medRxiv, doi.org/10.1101/2025.06.17.25328546
Peer-reviewed Papers
32. A facile and reproducible method for the purification of peptide- and protein-functionalized DNA nanostructures,
Schärf I., Paton A., Karakoc, B., Greul, B., Scheeder A., Nani P., Saludes Peris P., Zacharopoulou M., Glembockyte, V., Mela, I., JACS Au 2025 5 (12), 5917-5923, doi: 10.1021/jacsau.5c01209
31. A Modular, Lego-Like Microfluidic Platform for Multimodal Analysis of Biofilm Formation and Antimicrobial Response.
Islayem D., Arya S., Yasmeen N., Hallfors N., Ngoc H., Alkhatib S., Mela I., Anwar S., Truong V., Pappa A.M. Adv. Mater. Interfaces 2025, e00303. https://doi.org/10.1002/admi.202500303
30. Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein.
Zacharopoulou M., Seetaloo N., Ross J., Stephens A.D., Fusco G., McCoy T.M., Dai W., Mela I, Fernandez-Villegas A., Martel A., Routh A.F., De Simone A, Phillips J.J., Kaminski Schierle G.S. J Am Chem Soc. (2025);147(16):13131-13145. doi: 10.1021/jacs.4c13473.
29. Mutation of the ALS-/FTD-associated RNA-binding protein FUS affects axonal development
van Tartwijk F., Wunderlich LCS, Mela I., Makarchuk S., Jakobs MAH., Qamar S., Franze K., Kaminski Schierle GS., St George-Hyslop PH., Qiaojin Lin J., Holt CE, Kaminski CF., J Neurosci. 2024 Jul 3;44(27):e2148232024. doi: 10.1523/JNEUROSCI.2148-23.2024.
28. Molecular Mechanisms of Cationic Fusogenic Liposome Interactions with Bacterial Envelopes
Scheeder A, Brockhoff M, Ward EN, Kaminski Schierle GS, Mela I*, Kaminski CF*, J Am Chem Soc. 2023 Dec 27;145(51):28240-28250. doi: 10.1021/jacs.3c11463
27. α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons
Stephens AD, Villegas AF, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF, Kaminski Schierle GS. Commun Biol. 2023 May 15;6(1):526. doi: 10.1038/s42003-023-04884-1
26. Multiparametric Sensing of Outer Membrane Vesicle-Derived Supported Lipid Bilayers Demonstrates the Specificity of Bacteriophage Interactions
Bali K, McCoy R, Lu Z, Treiber J, Savva A, Kaminski CF, Salmond G, Salleo A, Mela I, Monson R, Owens RM, ACS Biomater Sci Eng. 2023 Jun 12;9(6):3632-3642. doi: 10.1021/acsbiomaterials.3c00021
25. Biosensor for Multimodal Characterization of an Essential ABC Transporter for Next-Generation Antibiotic Research
Bali K, Guffick C, McCoy R, Lu Z, Kaminski CF, Mela I, Owens RM, van Veen HW, ACS Appl Mater Interfaces. 2023 Mar 15;15(10):12766-12776. doi: 10.1021/acsami.2c21556.
24. Nanoscale Features of Tunable Bacterial Outer Membrane Models Revealed by Correlative Microscopy
Bali K., Mohamed Z., Scheeder A., Pappa A.M., Daniel S., Kaminski C.F., Owens R.M., Mela I*. Langmuir, 2022, 38, 29, 8773–8782, 10.1021/acs.langmuir.2c00628
23. Z-alpha-1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state
Chambers J.E. †, Zubkov N.†, Kubánková M., Nixon-Abell J., Mela I., Abreu S., Schwiening M., Lavarda G., López‐Duarte I., Torres T., Kaminski C.F., Holt L.J., Avezov E., Huntington J.E., St George Hyslop P., Kuimova M.K., Marciniak S.J. Sci. Adv.8, eabm2094 (2022), https://doi.org/10.1126/sciadv.abm2094
22. Tuning Riboflavin Derivatives For Photodynamic Inactivation of Pathogens
Crocker L., Lee J.H., Mital S., Mills G., Schack S., Bistrovic-Popov A., Franck C., Mela I., Kaminski C.F., Christie G., Fruk L., Sci Rep 12, 6580 (2022). https://doi.org/10.1038/s41598-022-10394-7
21. The SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress
Scherer K. M., Mascheroni L., Carnell G. W., Wunderlich L. C. S., Makarchuk S., Brockhoff M., Mela I., Fernandez-Villegas I., Barysevich M., Stewart H., Suau Sans M., George C. L., Lamb J. R., Kaminski-Schierle G.S., Heeney J. L., Kaminski C. F. Sci Adv. 2022 Jan 7;8(1):eabl4895. doi: 10.1126/sciadv.abl4895.
20. Advances in the Sensing and Treatment of Wound Biofilms
Darvishi S., Tavakoli S., Kharaziha M., Girault H.H., Kaminski C.F., Mela I*. Angew. Chem. Int. Ed. 2022, 61, e202112218; Angew. Chem. 2022, 134, e202112218.I https://doi.org/10.1002/anie.202112218
19. Revealing nanomechanical domains and their transient behavior in mixed-halide perovskite films
Mela I.#, Poudel C.#, Anaya M.*, Delport G., Frohna K., Macpherson S., Doherty T., Scheeder, A., Stranks S.D.*, Kaminski C.F.*, Adv Funct Mater, 2021, 31, 2100293, doi.org/10.1002/adfm.202100293
18. Guided Assembly and Patterning of Intrinsically Fluorescent Amyloid Fibers with Long-Range Order
Hecker, L., Wang, W., Mela, I., Fathi, S., Poudel, C., Soavi, G., Huang, Y.Y.S., Kaminski, C.F. Nano Lett. 2021, 21, 2, 938–945, doi.org/10.1021/acs.nanolett.0c03672
17. Design of Biologically Active Binary Protein 2D Materials
Ben-Sasson AJ, Watson JL, Sheffler W, Camp Johnson M, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Ruohola-Baker H, Kollman JM, Derivery E, Baker D, Nature, 2021 Jan;589(7842):468-473. doi: 10.1038/s41586-020-03120-8
16. Nano-vehicles give new lease of life to existing antimicrobials (Invited)
Mela. I*, Kaminski C.F., Emerg Top Life Sci, Dec 17;4(6):555-566. doi: 10.1042/ETLS20200153
15. Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?
Zabolotnaya E., Mela. I., Henderson R.M., Robinson N.P, Biochem Soc Trans, (2020) 48 (6): 2359–2376, doi.org/10.1042/BST20170168
14. Modes of action of the archaeal Mre11-Rad50 DNA-repair complex revealed by atomic force microscopy.
Zabolotnaya E., Mela. I, Williamson MJ, Bray SM, Yau SK, Papatziamou D, Edwardson J.M., Robinson* N.P., Henderson* R.M, Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14936-14947. doi: 10.1073/1915598117
13. DNA origami nanostructures as a tool for the targeted destruction of bacteria.
Mela I*, Vallejo-Ramirez P. P., Makarchuk S., Christie G., Henderson R.M., Sugiyama H., Endo M., Kaminski C. F.*, Angewandte Chemie, https://doi.org/10.1002/anie.202002740
12. Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity.
Stephens, A.D, Zacharopoulou, M., Moons R., Fusco G., Seetaloo N., Chiki A., Woodhams, P.J., Mela I., Lashuel H.A., Philips J.J., De Simone A., Sobott, F., Schierle, G., Nat Commun 11, 2820 (2020). https://doi.org/10.1038/s41467-020-16564-3
11. High-throughput, multi-parametric and correlative fluorescence lifetime imaging.
Poudel, C., Mela, I., Kaminski C.F., Methods Appl. Fluoresc. 8 024005, https://doi.org/10.1088/2050-6120/ab7364
10. Molecular architecture of the SYCP3 fibre and its interaction with DNA.
Bollschweiler D., Radu L., Plitzko J.M., Henderson R. M., Mela I.*, Pellegrini L.*, Open Biol. 9: 190094. http://dx.doi.org/10.1098/rsob.190094
9. Super-condenser enables label-free nanoscopy.
Ströhl, F., Opstad, I.S., Tinguely, J.-C, Dullo, F.T., Mela, I., Osterrieth, J.W.M., Ahluwalia, B.S., Kaminski, C.F., Optics Express, Volume 27, Issue 18, 2 September 2019, Pages 25280-25292
8. On‐Chip Super‐Resolution Imaging with Fluorescent Polymer Films.
Pang, C. L., Li, J. X., Tang, M. W., Wang, J. P., Mela, I., Ströhl, F., Hecker, L., Shen, W. D., Liu, Q. L., Liu, X.,Wang, Y. N., Zhang, H., Xu, M., Zhang, X. H., Liu, X., Yang, Q., Kaminski, C. F Adv. Funct. Mater. 2019, 1900126.
7. The Effect of Fluoride on the Structure, Function, and Proteome of Intestinal Epithelia.
Amadeu de Oliveira, F., MacVinish, L.J., Amin, S., Herath, D., Jeggle, P., Mela, I., Pieri, M., Sharma, C., Jarvis, G.E., Levy, F.M., Santesso, M.R., Khan, Z.N., Leite, A.L., Oliveira, R.C., Buzalaf, M.A.R. and Edwardson, J.M. Env. Toxicol. 2018 Jan;33(1):63-71. doi: 10.1002/tox.22495
6. Cartilage-like electrostatic stiffening of responsive cryogel scaffolds.
Offeddu GS, Mela I, Jeggle P, Henderson RM, Smoukov SK, Oyen ML. Sci Rep. 2017 Feb 23;7:42948. doi: 10.1038/srep42948.
5. Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
Capalbo L, Mela I, Abad MA, Jeyaprakash AA, Edwardson JM, D'Avino PP. Open Biol. 2016 Oct;6(10). doi: 10.1098/rsob.160248
4. Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Hanna MG4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287.
3. Inducible presynaptic glutamine transport supports glutamatergic transmission at the calyx of Held synapse.
Billups D, Marx MC, Mela I, Billups B. J Neurosci. 2013 Oct 30;33(44):17429-34. doi: 10.1523/JNEUROSCI.1466-13.2013.
2. Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy.
Mela I, Kranaster R, Henderson RM, Balasubramanian S, Edwardson JM., Biochemistry, 2012 Jan 17;51(2):578-85.
doi: 10.1021/bi201600g
1. Charge reversal by salt-induced aggregation in aqueous lactoferrin solutions.
Mela I, Aumaitre E, Williamson AM, Yakubov GE. Colloids Surf B Biointerfaces. 2010 Jun 5;78(1):53-60.
doi: 10.1016/j.colsurfb.2010.02.011.2