Publications
Novel modes of action of the archaeal Mre11-Rad50 DNA-repair complex revealed by atomic force microscopy.
Zabolotnaya E., Mela. I, Williamson M., Edwardson J.M., Robinson* N.P., Henderson* R.M, Proceedings of the National Academy of Sciences Jun 2020, 201915598; DOI: 10.1073/pnas.1915598117
DNA origami nanostructures as a tool for the targeted destruction of bacteria.
Mela I*, Vallejo-Ramirez P. P., Makarchuk S., Christie G., Henderson R.M., Sugiyama H., Endo M., Kaminski C. F.*, Angewandte Chemie, https://doi.org/10.1002/anie.202002740
Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity.
Stephens, A.D, Zacharopoulou, M., Moons R., Fusco G., Seetaloo N., Chiki A., Woodhams, P.J., Mela I., Lashuel H.A., Philips J.J., De Simone A., Sobott, F., Schierle, G., Nat Commun 11, 2820 (2020). https://doi.org/10.1038/s41467-020-16564-3
High-throughput, multi-parametric and correlative fluorescence lifetime imaging.
Poudel, C., Mela, I., Kaminski C.F., Methods Appl. Fluoresc. 8 024005, https://doi.org/10.1088/2050-6120/ab7364
Molecular architecture of the SYCP3 fibre and its interaction with DNA.
Bollschweiler D., Radu L., Plitzko J.M., Henderson R. M., Mela I.*, Pellegrini L.*, Open Biol. 9: 190094. http://dx.doi.org/10.1098/rsob.190094
Super-condenser enables label-free nanoscopy.
Ströhl, F., Opstad, I.S., Tinguely, J.-C, Dullo, F.T., Mela, I., Osterrieth, J.W.M., Ahluwalia, B.S., Kaminski, C.F., Optics Express, Volume 27, Issue 18, 2 September 2019, Pages 25280-25292
On‐Chip Super‐Resolution Imaging with Fluorescent Polymer Films.
Pang, C. L., Li, J. X., Tang, M. W., Wang, J. P., Mela, I., Ströhl, F., Hecker, L., Shen, W. D., Liu, Q. L., Liu, X.,Wang, Y. N., Zhang, H., Xu, M., Zhang, X. H., Liu, X., Yang, Q., Kaminski, C. F Adv. Funct. Mater. 2019, 1900126.
Purification of Recombinant ESCRT-III Proteins and Their Use in Atomic Force Microscopy and In Vitro Binding and Phosphorylation Assays.
Capalbo, L., Mela, I., Abad, M.A., Jeyaprakash, A.A., Edwardson, J.M., D’Avino, P.P., Methods in Molecular Biology, Volume 1998, 2019, Pages 203-217
The Effect of Fluoride on the Structure, Function, and Proteome of Intestinal Epithelia.
Amadeu de Oliveira, F., MacVinish, L.J., Amin, S., Herath, D., Jeggle, P., Mela, I., Pieri, M., Sharma, C., Jarvis, G.E., Levy, F.M., Santesso, M.R., Khan, Z.N., Leite, A.L., Oliveira, R.C., Buzalaf, M.A.R. and Edwardson, J.M. Env. Toxicol. 2018 Jan;33(1):63-71. doi: 10.1002/tox.22495
Cartilage-like electrostatic stiffening of responsive cryogel scaffolds.
Offeddu GS, Mela I, Jeggle P, Henderson RM, Smoukov SK, Oyen ML. Sci Rep. 2017 Feb 23;7:42948. doi: 10.1038/srep42948.
Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
Capalbo L, Mela I, Abad MA, Jeyaprakash AA, Edwardson JM, D'Avino PP. Open Biol. 2016 Oct;6(10).
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Hanna MG4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. J Biol Chem. 2016 Jan 15;291(3):1014-27.
Inducible presynaptic glutamine transport supports glutamatergic transmission at the calyx of Held synapse.
Billups D, Marx MC, Mela I, Billups B. J Neurosci. 2013 Oct 30;33(44):17429-34.
Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy.
Mela I, Kranaster R, Henderson RM, Balasubramanian S, Edwardson JM., Biochemistry, 2012 Jan 17;51(2):578-85.
Charge reversal by salt-induced aggregation in aqueous lactoferrin solutions.
Mela I, Aumaitre E, Williamson AM, Yakubov GE. Colloids Surf B Biointerfaces. 2010 Jun 5;78(1):53-60.