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Mela lab
DNA nanotechnology
for targeted drug delivery
Latest news


Ioanna is invited to contribute to Viewpoint article in Nature Reviews Physics, on the Forty Years of Atomic Force Microscopy
Nature Reviews Physics celebrates 40 years of Atomic Force Microscopy. We are delighted to have been invited to contribute to this viewpoint article together with some of the leaders in the Atomic Force Microscopy Field! Read it here: https://www.nature.com/articles/s42254-026-00953-6


Congratulations to John on his Gates Scholarship!
Our very own MPhil student John Wang is awarded a Gates Scholarship to pursue a PhD in the lab starting October 2026. John will be working on further advancing our bacterial targeting toolkit and we are absolutely delighted that he will be continuing in the lab as a PhD student! Congratulations and well deserved! Never one to stay still, John was also interviewed on his success, project and life by Gates Cambridge, read his interview here: https://www.gatescambridge.org/about


New paper on bacterial targeting out!
A new paper from the lab is out in Angewandte Chemie! https://onlinelibrary.wiley.com/doi/full/10.1002/ange.202525762 We are delighted to see this paper out - we led the development of a targeting apparatus that can directly drive metal organic frameworks to bacteria, based on PNA/DNA hybrids. Thank you to David Fairen-Jimenez for the MOF expertise and to Clemens Kaminski for the imaging expertise! Congratulations to all, and especially the first authors Anna Scheeder and Jon


International Women's Day 2026
Ioanna gives a talk in the Department of Pharmacology on International women's day, discussing her path as a woman in Science (and Engineering!). Thank you to the Postgraduate and Postdoc committee for organising and everyone who attended - it was a great event!


New BHF grant for the lab!
We are delighted to have been awarded a BHF Project Grant, on DNA nanostructures for targeted fibrinolytic delivery, in collaboration with Prof. Matthew Harper . A big thank you to all lab members who have worked to support this application and especially Yuening Su for her beautiful platelet imaging!


Maria is at the 70th Biophysical Society Annual Meeting!
Maria represents the lab at the 70th Biophysical Society Annual Meeting in San Francisco, with a poster AND a talk on " Design of DNA-peptide nanostructures against intracellular targets in cancer" https://www.cell.com/biophysj/fulltext/S0006-3495(25)01774-6 Maria was awarded a Travel Award by the Biophysical Society - congratulations!


New paper out!
Izar Schaerf, visiting MSc student from Heidelberg University, lead a project aiming to develop a new method for the purification of peptide- and protein-functionalised nanostructures. Being able to easily and consistently purify nanostructures decorated with biologics is crucial to our work so we are very excited to see this paper out! Special thanks to the group of Viktorija Glembockyte at Heidelberg, who validated our method with their complex nanostructures. Read it here:


Our new highlight is now out!
Anna and Ioanna write a highlight on our work on fusogenic liposomes and their interactions with Gram-positive and Gram-negative bacteria, published in Volume 42 of Advances in Biomembranes and Lipid Self-Assembly . Read it here: https://doi.org/10.1016/bs.abl.2025.07.006


Welcome to our new lab members!
Today we are welcoming three new lab members, Yomna Gabr, who will be studying for a PhD on macro DNA origami arrays, Yuening Su, who will be studying for a PhD on the selective targeting of activated platelets and John Wang, who will be studying for an MPhil on the targeted delivery of novel antimicrobial compounds. Lovely to have you in the lab, all!


Ioanna gives a talk at the Royal Society Summer Science Exhibition
On the 5th July, Ioanna gave a talk at the Royal Society Summer Science Exhibition on "Can origami made of DNA help us kill superbugs". It was a fun day with audience members of all ages - thank you to the lab members, current and old that attended!


Mela lab Away Day 2025
It’s (not) away day time again! On the 26th June, we spent a day at Emmanuel College, Cambridge , discussing the lab’s progress on DNA nanotechnology for drug delivery and on aptamer selection for bacterial and mammalian targets. Very excited to see projects coming together and everyone’s hard work coming to fruition! This year, we were again very lucky to have with us visitors to the lab: Manon Libotte, PhD student at the University of Bologna, Italy; Bianca Greul,


Our new book chapter on "Targeting Bacterial Cells with DNA Nanostructures" is out!
Anna and Ioanna write a protocol on targeting bacteria with DNA nanostructures for the third edition of DNA Nanotechnology - Methods and Protocols, published by Springer Nature and edited by Professor Giampaolo Zuccheri, University of Bologna. Read it here: https://link.springer.com/protocol/10.1007/978-1-0716-4394-5_8
Contact
+44 (0) 1223 334176
University of Cambridge
Department of Pharmacology
Tennis Court Road
Cambridge
CB2 1PD
United Kingdom
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